UDC 615.2:[616.24-002:616.98:578.834.1]-036-074/-078

Comparative Analysis of Complications in Different Combinations of Immunosuppressive Therapy After Kidney Transplantation

Comparative Analysis of Complications in Different Combinations of Immunosuppressive Therapy After Kidney Transplantation
©Ashimov Zh., ORCID: 0000-0002-0581-4922, SPIN-code: 2430-8820, Dr. habil., Institute of Cardiac Surgery and Organ Transplantation, Bishkek, Kyrgyzstan
©Gaibyldaev Zh., ORCID: 0000-0002-1157-8655, Institute of Cardiac Surgery and Organ Transplantation, Bishkek, Kyrgyzstan
© Abibillaev D., ORCID: 0000-0002-4660-3064, SPIN-code: 9004-0598, Institute of Cardiac Surgery and Organ Transplantation, Bishkek, Kyrgyzstan
©Kocyigit F., Izmir, Turkey, fuatkocyigit@hotmail.com

Abstract. In the length of time, a wide variety of drug combinations emerged in the management of post-transplantation therapy in order to improve the survival of the recipient and graft. However, the efficacy and safety of the applied combinations regarding the rejection and other complications are continuing to be the subject of research. In our study, our aim is to compare the effects of various combinations, namely cyclosporine with mycophenolate mofetil/mofetil mycophenolic acid with prednisolone and tacrolimus with mycophenolate mofetil/mofetil mycophenolic acid with prednisolone in a length of time. Methods. A total of 204 patients included into the study who received post-renal transplantation treatment in Scientific-Research Institute of Heart Surgery and Organs Transplantation and followed-up over a 10-year period. The estimated survival probabilities in the study were determined by the Kaplan-Meier method; whereas intragroup comparisons were evaluated by Log-rang, Breslow, and Tarone-Ware tests. Complications occurred in patients with combinations were analyzed by Chi-square and its alternatives. Hazard risk factors were tested by Cox regression analysis. Results. Of these 204 patients, 36 received Cyclosporin combination (CCG) and 168 Tacrolimus combination (TCG). The estimated life expectancy of the patients of TCG was significantly longer than the CCG ones. Furthermore, gender and age did not have a significant effect on survival depending on time, however, gender and age-related hazard factor showed a significant difference in the groups. It was determined that chronic rejection was significantly different in patients who used tacrolimus combinations, the difference was close to the significant value in acute rejection analysis. Other adverse events, namely, infection, tumour and organ damage were statistically less common in the patient group treated with tacrolimus combinations. Conclusion. In general, TCG showed better results in contrast to CCG.

Keywords: post-transplantation therapy, survival estimates, drug combinations, acute rejection, chronic rejection, hazard factor.

Сравнительный анализ осложнений при разных комбинациях иммуносупрессивной терапии после трансплантации почки
©Ашимов Ж. И., ORCID: 0000-0002-0581-4922, SPIN-код: 2430-8820, д-р мед. наук, Научно-исследовательский институт хирургии сердца и трансплантации органов, г. Бишкек, Кыргызстан
©Гайбылдаев Ж. Ж., ORCID: 0000-0002-1157-8655, Научно-исследовательский институт хирургии сердца и трансплантации органов, г. Бишкек, Кыргызстан
©Абибиллаев Д. А., ORCID: 0000-0002-4660-3064, SPIN-код: 9004-0598, Научно-исследовательский институт хирургии сердца и трансплантации органов, г. Бишкек, Кыргызстан
©Коцигит Ф., г. Измир, Турция, fuatkocyigit@hotmail.com

Аннотация. В данное время для контроля посттрансплантационной иммуносупрессии появилось большое разнообразие комбинаций препаратов, направленных на улучшение выживаемости реципиента и трансплантата. Однако эффективность и безопасность применяемых комбинаций в отношении отторжения и других осложнений продолжают оставаться предметом исследований. Цель исследования состоит в том, чтобы сравнить эффекты различных комбинаций, а именно циклоспорин А, микофенолат мофетил, микофеноловая кислота, преднизолон с такролимусом, микофенолатом мофетила, микофеноловой кислотой, преднизолоном в течение длительного времени.

Ключевые слова: посттрансплантационная терапия, оценка выживаемости, комбинации препаратов, острое отторжение, хроническое отторжение, фактор риска.

Ссылка для цитирования:

Ashimov Zh., Gaibyldaev Zh., Abibillaev D., Kocyigit F. Comparative Analysis of Complications in Different Combinations of Immunosuppressive Therapy After Kidney Transplantation // Бюллетень науки и практики. 2021. Т. 7. №2. С. 152-162. https://doi.org/10.33619/2414-2948/63/13

Cite as (APA):

Ashimov, Zh., Gaibyldaev, Zh., Abibillaev, D., & Kocyigit, F. (2021). Comparative Analysis of Complications in Different Combinations of Immunosuppressive Therapy After Kidney Transplantation. Bulletin of Science and Practice, 7(2), 152-162. https://doi.org/10.33619/2414-2948/63/13

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